WEBCAST

Bridging the scales: Leveraging iPSC's to identify the neurological and behavioural consequences of synaptic aberr…

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This webinar was recorded on 5 May 2025 as part of the PsychX webinar series.

Speaker: Michael Ziller, Germany

Outline: Schizophrenia is characterized by a wide range of alterations throughout the central nervous system, suggesting widespreaddisruptions in synapse function. However, it remains unclear, how altered synapse biology translates into neurophysiological and behavioral consequences. Here, we narrow this translational gap by establishing a research framework to bridge the scales from in vitro iPSC-based diseases modelling to in vivo deep patient phenotyping. Our results provide a direct connection between the molecular origins of synapse reduction in SCZ and its neurobiological and phenotypic consequences on the individual patient level.

PsychX webinar series: Mental health expertise should be readily available to all. PsychX conducts monthly sessions, fostering short and interactive discussions focused on translational neuroscience. This webinar series is organised by the ECNP PsychX Programme Committee.

This online series provides valuable insights for researchers and clinicians while promoting networking opportunities within the professional community.
 

Faculty

Michael Ziller

Speaker

University of Muenster | Germany

Chiara Fabbri

Chiara Fabbri

Moderator

University of Bologna | Italy