Why does a neurodevelopmental condition such as Autism Spectrum Disorder (ASD), which is associated with reduced reproductive fitness, remainprevalent in human populations? This presentation addresses this paradox by applying advanced evolutionary genomics approaches to the largest ASD genome-wide association study (GWAS) conducted to date, which remains unpublished.
The presentation will examine the contribution of both evolutionarily constrained and rapidly evolving genomic regions, the differential roles of ancestral versus derived alleles, and the origin and persistence of ASD-associated variants from archaic humans to anatomically modern humans. Together, these findings highlight the complex interplay of evolutionary forces shaping the genetic architecture of ASD.
Title: Evolutionary genomics in autism spectrum disorder
Speaker: Ariadna Bada, Spain
Breaking Hot Topics webinar series: Following a record number of submissions to the Breaking Hot Topics Symposium at the 38th ECNP Congress in Amsterdam, the ECNP is proud to launch the Breaking Hot Topics webinar series. This new online series features selected runner-up presentations that showcase the most current and compelling science in neuropsychopharmacology.
The series aims to extend the conversation beyond the Congress, foster visibility for emerging work, and connect researchers across disciplines and borders.
