Title: Dopaminergic therapy for inflammation-related anhedonia in depression
Speaker: Jennifer Felger, USA
Outline: Inflammation is increased ~1/3 of patients with depression and has been associated with poor response to conventional antidepressants. A large literature has established that inflammation affects brain circuits and neurotransmitters to lead to depressive symptoms like reduced motivation and anhedonia. Our recent works shows that drugs that increase dopamine improve reward circuit function and motivation in depression with higher inflammation. This work opens new avenues for dopaminergic therapies in this high inflammation phenotype of depression and provides a translational platform of brain and behavioral targets to study novel therapies to block inflammation or its effects on the brain.
PsychX webinar series: Mental health expertise should be readily available to all. PsychX conducts monthly sessions, fostering short and interactive discussions focused on translational neuroscience. This webinar series is organised by the ECNP PsychX Programme Committee.
This online series provides valuable insights for researchers and clinicians while promoting networking opportunities within the professional community.
